Matrix metalloproteinases (MMPs) are a large group of
zinc-dependent extracellular endopeptidase proteinases involved in
the cleavage of extracellular matrix macromolecules. MMPs play an
important role in normal physiology, migration of inflammatory
cells and the repair process after tissue damage. In this book, the
authors present current research in the study of the biology,
functions and clinical implications of matrix metalloproteinases.
Topics discussed include TGF-B and MMPs as a complex regulatory
loop in tumor progression; MMPs role in the pathogenesis of
osteoarthritis; gelatinases in the skin; detecting MMP activity in
vivo; MMPs in renal fibrosis; macrophage migration inhibitory
factor as a mediator of MMP production; MMP regulation by
macrolides in cardiac disorders and MMPs in neural plasticity and
disease.
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