Molecular Defects in Cardiovascular Diseaseprovides an in-depth
discussion of the molecular mechanisms underlying the genesis of
cardiovascular defects and the implications this has on current and
emerging targeted therapeutics. Divided into three sections, this
book covers the scientific foundations of our present understanding
as well as the array of clinical manifestations and their
treatment. The first section covers Molecular Mechanisms of Heart
Disease, with discussion of the development of cardiovascular
dysfunction. The remaining two sections provide a more clinical
focus. The second, Cardiac Hypertrophy and Heart Failure deals with
metabolic derangements, Ca2+ handling, and subcellular remodeling.
It illustrates the wide variety of molecular defects which may
serve as targets associated with the transition from cardiac
hypertrophy to advanced heart failure. The third section,
Hypertension and Diabetes, provides molecular rationale for the
pathogenesis of hypertension and diabetic cardiomyopathy, as well
as highlighting the importance of hormones toward this end.
A necessary resource for clinicians and researchers, this book
elucidates the experimental basis of the practice of cardiology. It
is the culmination of our advances in the understanding of
cardiovascular molecular biology and a blueprint for the
efficacious use of targeted therapies.
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