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Myocardial Ischemia - Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8-11, 1986, Winnipeg, Canada (Paperback, Softcover reprint of the original 1st ed. 1987)
Loot Price: R1,581
Discovery Miles 15 810
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Myocardial Ischemia - Proceedings of a Satellite Symposium of the Thirtieth International Physiological Congress July 8-11, 1986, Winnipeg, Canada (Paperback, Softcover reprint of the original 1st ed. 1987)
Series: Developments in Cardiovascular Medicine, 67
Expected to ship within 10 - 15 working days
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Whenever the coronary flow is inadequate to provide enough oxygen
to meet the energy demands of the tissue, the heart becomes
ischemic. Manifestations of myocardial ischemia include depression
in contractile activity, changes in metabolic pattern,
abnormalities in ultrastructure, and alterations in membrane
potential. Ischemic changes during the early phase are reversible
but as the period of ischemia is extended, the injury becomes
irreversible. The transition from reversible to irreversible
ischemic injury is usually associated with some membrane defects.
It is worthwhile to consider that the irreversible damage to the
ischemic myocardium occurs when the sarcolemmal membrane is altered
in suoh a way that it would promote 2 a net gain of ca + in the
cardiac cell upon reinstitution of blood flow. Suoh a lesion could
result when mechanisms for the entry as well as removal 2 of ca +
from the myocardial oell become defective. In this regard, 2
depression of the sarcolemmal ca + pump would favour the oocurrenoe
of 2 intracellular ca + overload. Furthermore, inhibition of the
Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould
then increase the 2 2 intracellular concentration of ca + through
the sarcolemmal Na+-ca + exchange mechanism. In faot recent studies
have revealed an inhibition of 2 the sarcolemmal Na+-ca + exchange
mechanism in the ischemic heart and this 2 change could also
contribute towards the occurrence of intracellular ca + 2 overload.
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