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Environmental Neuroscience - Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop (Paperback)
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Environmental Neuroscience - Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop (Paperback)
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Humans are potentially exposed to more than 80,000 toxic chemicals
in the environment, yet their impacts on brain health and disease
are not well understood. The sheer number of these chemicals has
overwhelmed the ability to determine their individual toxicity,
much less potential interactive effects. Early life exposures to
chemicals can have permanent consequences for neurodevelopment and
for neurodegeneration in later life. Toxic effects resulting from
chemical exposure can interact with other risk factors such as
prenatal stress, and persistence of some chemicals in the brain
over time may result in cumulative toxicity. Because
neurodevelopmental and neurodegenerative disorders - such as
attention-deficit hyperactivity disorder and Parkinson's disease -
cannot be fully explained by genetic risk factors alone,
understanding the role of individual environmental chemical
exposures is critical. On June 25, 2020, the National Academies of
Sciences, Engineering, and Medicine's Forum on Neuroscience and
Nervous System Disorders hosted a workshop to lay the foundation
for future advances in environmental neuroscience. The workshop was
designed to explore new opportunities to bridge the gap between
what is known about the genetic contribution to brain disorders and
what is known, and not known, about the contribution of
environmental influences, as well as to discuss what is known about
how genetic and environmental factors interact. This publication
summarizes the presentation and discussion of the workshop. Table
of Contents Front Matter 1 Introduction and Background 2
Neurotoxicants and Their Risks to Human Health 3 The Exposome and
Exploring the Multiple Factors That Contribute to Neurotoxicity 4
Chemical Toxicants as Drivers of Abnormal Neurodevelopment and
Neurodegeneration 5 Research Gaps and Opportunities 6 Potential
Opportunities for Action and Multidisciplinary Collaborations
Appendix A: References Appendix B: Workshop Agenda
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