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Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression - Workshop Summary (Paperback)
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Enabling Discovery, Development, and Translation of Treatments for Cognitive Dysfunction in Depression - Workshop Summary (Paperback)
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Major depressive disorder (MDD) is recognized worldwide as a major
cause of disability, morbidity, and mortality. According to the
World Health Organization, unipolar depressive disorders affect
more than 150 million people around the world and represent the
leading cause of years lost due to disability among both men and
women. In the United States alone, nearly 8 percent of persons over
the age of 12 report current depression. MDD has long been defined
primarily as a mood disorder. However,more recently people have
begun to recognize effects on cognition as a major contributor to
the disablement that accompanies depression and to consider this an
underrecognized treatment target for depression. To explore how
best to enable the discovery, development, and translation of
treatments for cognitive dysfunction in depression, including a
focus on the regulatory path forward, the Institute of Medicine's
Forum on Neuroscience and Nervous Disorders convened key
stakeholders at a workshop in February 2015. This report summarizes
the presentations from expert speakers and discussions among
workshop participants. Table of Contents Front Matter 1
Introduction and Overview 2 The Burden of Cognitive Dysfunction in
Depression 3 State of the Science: Treatment Development 4
Challenges and Potential Solutions to Enable Development of
Successful Treatments 5 Regulatory Issues 6 Lessons Learned from
the Schizophrenia Field Appendix A: References Appendix B: Workshop
Agenda Appendix C: Registered Attendees
General
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