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Technological Challenges in Antibiotic Discovery and Development - A Workshop Summary (Paperback)
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Technological Challenges in Antibiotic Discovery and Development - A Workshop Summary (Paperback)
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Technological Challenges in Antibiotic Discovery and Development is
the summary of a workshop convened by the Chemical Sciences
Roundtable in September 2013 to explore the current state of
antibiotic discovery and examine the technology available to
facilitate development. Through formal presentations and panel
discussions, participants from academia, industry, federal research
agencies discussed the technical challenges present and the
incentives and disincentives industry faces in antibiotic
development, and identified novel approaches to antibiotic
discovery. Antibiotic resistance is a serious and growing problem
in modern medicine and it is emerging as a pre-eminent public
health threat. Each year in the United States alone, at least two
million acquire serious infections with bacteria that are resistant
to one or more antibiotics, and at least 23,000 people die annually
as a direct result of these antibiotic-resistant infections. In
addition to the toll on human life, antibiotic-resistant infections
add considerable and avoidable costs to the already overburdened
U.S. health care system. This report explores the challenges in
overcoming antibiotic resistance, screening for new antibiotics,
and delivering them to the sites of infection in the body. The
report also discusses a path forward to develop the next generation
of potent antimicrobial compounds capable of once again tilting the
battle against microbial pathogens in favor of humans.
Technological Challenges in Antibiotic Discovery and Development
gives a broad view of the landscape of antibiotic development and
the technological challenges and barriers to be overcome. Table of
Contents Front Matter 1 Introduction and Overview 2 Challenges In
Overcoming Antibiotic Resistance 3 Challenges in Screening 4
Challenges In Drug Delivery 5 General Observations Appendix A:
Statement of Task Appendix B: Agenda Appendix C: Biographical
Information Appendix D: Workshop Attendees
General
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