Alzheimer's disease is the most common cause of senile dementia.
Since the discovery in 1984 of the amyloid ?-peptide (A?) as the
core protein of the senile plaques present in the brains of
Alzheimer's disease sufferers, an immense amount of research has
gone into mapping out the molecular basis of this debilitating
disease. The aim of Alzheimer's Disease: Methods and Protocols is
to bring together the main biochemical, cell biological, and
molecular biological techniques and approaches that are being used
to investigate the molecular basis of Alzheimer's disease. This
volume begins with chapters of an introductory/ review nature.
Chapter 1 provides a historical introduction to Alzheimer's d- ease
with particular emphasis on the central role played by A? and its
re- tion to tau. Chapter 2 examines the genetics underlying this
neurodegenerative disease, covering the amyloid precursor protein,
apolipoprotein E, and the presenilins. Chapter 3 presents an
overview of currently available therapeutic agents and prospects
for drugs of the future.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Molecular Medicine, 32 |
| Release date: |
November 2010 |
| First published: |
2000 |
| Editors: |
Nigel M. Hooper
|
| Dimensions: |
229 x 152 x 23mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
408 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2000 |
| ISBN-13: |
978-1-61737-161-5 |
| Categories: |
Books >
Medicine >
Clinical & internal medicine >
Neurology & clinical neurophysiology
|
| LSN: |
1-61737-161-0 |
| Barcode: |
9781617371615 |
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