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Interferons and Their Applications (Paperback, Softcover reprint of the original 1st ed. 1984)
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Interferons and Their Applications (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: Handbook of Experimental Pharmacology, 71
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Today, the basic mood of researchers and clinical investigators,
both at the center and on the periphery of interferon studies, is
optimistic regarding the future of interferons as therapeutic
substances. Many also feel these polypeptides will prove invaluable
probes in unraveling certain fundamental biochemical processes
which control the life cycle and developmental pattern of many
human cells. In contrast, only a year or two ago, this optimism had
given way to an attitude almost of disenchantment as public and
scientific expectations were raised steeply, then rapidly waned, as
it turns out, prematurely. Both the mUltiple actions of interferons
(a virtual cascade of biochemical reactions may be induced, as
documented herein) and the high visibility of interferon research
provided by the millions of dollars invested both by national
health agencies and by multinational pharmaceutical companies,
contributed to an upsweep in public attention to drug development
probably unprecedented in this century. Virtually every oncologist,
it would seem, was plagued by requests for the experimental agent,
although they already had therapies of more proven value. As
recently as 1980, even though interferon had achieved success
against certain cancers and certain viral diseases, the variability
in clinical results was seemingly ever present and little evidence
emerged to suggest interferons could cure advanced diseases. Why
then the resurgence of an optimistic mood? There are almost always
many elements which contribute to happiness, and this is certainly
true of the broad frontier of interferon and its place in
biochemical research and treatment.
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