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Books > Professional & Technical > Mechanical engineering & materials > Materials science > Mechanics of solids > Dynamics & vibration
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Structure and Dynamics of RNA (Paperback, Softcover reprint of the original 1st ed. 1986)
Loot Price: R1,583
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Structure and Dynamics of RNA (Paperback, Softcover reprint of the original 1st ed. 1986)
Series: NATO Science Series A:, 110
Expected to ship within 10 - 15 working days
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This volume contains contributions from the speakers at the NATO
Advanced Research Workshop on "3D 5tructure and Dynamics of RNA",
which was held in Renesse, The Netherlands, 21 - 24 August, 1985.
Two major developments have determined the progress of nucleic acid
research during the last decade. First, manipulation of genetic
material by recombinant DNA methodology has enabled detailed
studies of the function of nucleic acids in vivo. 5econd, the use
of powerful physical methods, such as X-ray diffraction and nuclear
magnetic resonance spectroscopy, in the study of biomacromolecules
has provided information regarding the structure and the dynamics
of nucleic acids. Both developments were enabled by the advance of
synthetic methods that allow preparation of nucleic acid molecules
of required sequence and length. The basic understanding of nucleic
acid function will ultimately depend on a close collaboration
between molecular biologists and biophy sicists. In the case of
RNA, the ground rules for the formation of secondary structure have
been derived from physical studies of oligoribonucleotides.
Powerfull spectroscopic techniques have revealed more details of
~~A structure including novel conformations (e.g. left-handed
Z-RNA). A wealth of information has been obtained by studying the
relatively small transfer RNA molecules. A few of these RNAs have
been crystallized, enabling determination of their
three-dimensional structure. It has become apparent that
"non-classical" basepairing between distal nucleotides gives rise
to tertiary interactions, determining the overall shape of the
molecule.
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