Itopride, a novel prokinetic agent is unique and different from the
available prokinetics because of its dual mode of action and lack
of significant drug interaction potential. Itopride is a newly
developed prokinetic agent, which enhances gastric motility through
both anti-dopaminergic and anti-acetylcholinesterage actions. It is
best candidate for Gastro Esophageal Reflux Disease. Itopride 50mg
can be given thrice in a day for Treatment of GERD. By developing
the sustain release formulation of Itopride hydrochloride, the
frequency of drug can be reduce to once only to obtain good
therapeutic response. The prepared formulation is usually taken on
an empty stomach about an hour before meals. Sustained release
tablet of Itopride Hydrochloride was prepared by using combination
of HPMC grade as matrix forming material. The influence of amount
of Hydroxypropyl Methylcellulose K15M and Hydroxypropyl
Methylcellulose K100M on release of Itopride hydrochloride was
studied using Central composite design. The optimized Formulation
FB7 had given prolonged drug release up to 24 hr. It also had
desired drug release kinetics and it was found to be stable after 1
month at accelerated conditions.
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