The increased incidence of pancreatic cancer in the Western world
and its grave prognosis has resulted in an urgency for research in
this area. Until now the available data on toxicology of the
pancreas has been few and fragmentary, scattered throughout the
literature. A benchmark volume, Toxicology of the Pancreas pulls
together information in this neglected area of toxicological
research and highlights fundamental research performed in the last
ten years. Leaders in the field discuss important structures, the
detoxification and toxification process at the cellular and
sub-cellular level, the distribution of phase 1 and phase 2
drug-metabolizing enzymes and their role in pancreatic disease, and
the role of diet and toxicants on pancreatic disease. The book also
covers the role of altered genes in the integrity of the pancreas
and explores comparative toxicology in humans and in the lab
species used in testing. Illustrated with histological, electron
microscopical, and immunohistochemical formats, this book provides
a comprehensive and novel presentation of biological and
toxicological data. It stands alone as a reliable resource of
information easily accessible to professionals in different
disciplines.
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