Traditionally, oligodendrocytes have been assumed to play a minor
supporting role in the central nervous system and their importance
has generally been overlooked. For the first time, this book
provides a dedicated review of all of the major aspects of
oligodendrocyte biology, including development, organization,
genetics, and immunobiology. Later chapters emphasize the
importance of this underestimated cell to the mammalian central
nervous system by exploring the role of myelin synthesis and
maintenance in neural disease and repair. Particular attention is
paid to multiple sclerosis (MS), arguably the prime example of an
acquired demyelinating disease, with detailed examinations of the
current concepts regarding demyelination, oligodendroglial damage,
and remyelination in MS lesions.
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