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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Relaxing and Contracting Factors - Biological and Clinical Research (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R5,651
Discovery Miles 56 510
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Relaxing and Contracting Factors - Biological and Clinical Research (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: The Endothelium
Expected to ship within 10 - 15 working days
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It is an exciting task to be the editor of the first monograph
covering a new area of the biomedical sciences. Since the first
report in 1980 by Robert Furchgott and colleagues (see Chapter 1)
of the evidence of endothelium-dependent relaxation in isolated
arteries, there are ever increasing numbers of vascular
physiologists and pharmacologists who are scraping away the
endothelium to look into its role in cardiovascular con trol. And
the more one looks, the more one discovers. Not only is the list of
substances that can induce endothelium-dependent relaxations im
pressively long, but these intriguing cells can also secrete
vasoconstrictor substances. The ability of the endothelium to
modulate the degree of con traction of the underlying smooth muscle
is an ancestral property of the blood vessel wall, illustrating the
logic of nature, since the endothelial cells are located in the
best possible strategic location to continuously monitor the
properties (chemical or physical) of the blood. And more and more
data emerge suggesting that in several cardiovascular diseases per
turbations in endothelium-dependent responses are one of the early
signs of the abnormal process. Thus, the importance of
endothelium-dependent responses, triggered by the intellectual
curiosity of one of the pioneers of vascular physiology and
pharmacology, is now recognized not only by basic scientists, but
also by all concerned with the cardiovascular diseases. The purpose
of this monograph is to provide them with a reference work, so that
they know where to start."
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