The blood-brain barrier (BBB) is a highly regulated system that
maintains brain allostasis. BBB achieves its main function by
transporting blood to brain glucose, amino acids and other
molecules needed for proper neural physiology, while extruding from
the brain molecules derived from neural and glial metabolism that
may have neurotoxic properties. In this book, the authors present
topical research in the study of blood-brain barriers including
their local and temporal regulation during normal and altered
physiological states; the therapeutic opportunities of
efflux-transporters at the blood-brain barrier; novel strategies to
restore blood-brain barrier integrity after brain injury;
evaluation of the blood-cerebrospinal fluid barrier in neurological
diseases and blood-brain barrier in hepatic encephalopathy.
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