Neuronal migration is a unique process during the development of
brain structure. Although cerebral anomalies resulting from
impaired migration have been identified for nearly a century, most
of our knowledge has accumulated in the last decade. Disorders of
neuronal migration are causes of mental handicap, autism, and
epilepsy. Many are genetically determined and need precise
diagnosis to provide genetic counselling.
This book addresses the various aspects of neuronal migration
disorders in an ordered way. It will help the clinician to acquire
insight as well as proficiency in diagnosis. Individual chapters
describe subgroups including lissencephalies, subependymal
heterotopia, non-lissencephalic cortical dysplasias, anomalies of
the corpus callosum, hemimegalencephaly, schizencephaly,
polymicrogyria and multisystem disorders with impaired migration
such as chromosomal and metabolic syndromes. Neuroradiological and
genetic data are provided with the respective chapters.
Although the book is intended for clinical practice, it provides
core information for all interested in this important biological
process.
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