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Ig Superfamily Molecules in the Nervous System (Hardcover)
Loot Price: R7,611
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Ig Superfamily Molecules in the Nervous System (Hardcover)
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A vast number of neural cell surface glycoproteins belonging to the
immunoglobulin superfamily have been isolated over the past two
decades. In functional studies, many of them have been shown to
confer adhesive properties to cells and to play an important role
in developmental processes such as cell migration and axon
outgrowth. Recent observations implicate Ig superfamily adhesion
molecules in the regulation of activity-dependent synaptic
plasticity, in regeneration after neural trauma, as well as in the
pathogenesis of malformations in the developing nervous systems.
This book summarizes the molecular features and some of the
cellular functions of this important class of cell surface
molecules. It includes detailed information on the molecular
structure of the immunoglobulin fold, the common domain of these
proteins, the molecular interactions between various neural Ig
superfamily members and their role in signal transduction, as well
as the role of Ig superfamily adhesion molecules in axon guidance
during both vertebrate and invertebrate neurogenesis. Recent
observations on a role for these molecules in activity-dependent
synaptic plasticity and in the regeneration of injured axons in the
peripheral and central nervous system are described. A discussion
on the connection between Ig superfamily adhesion molecules and
medical genetics is also provided.
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