This research focuses on gene therapy as well as immunotherapy to
target the breast cancer stem cells in breast cancer treatment.
Breast cancer stem cells were isolated and proliferated from
malignant breast tumors. About gene therapy, we used knockdown gene
therapy to suppress the CD44 expression. CD44 holds an important
role in stemness maintenance of breast cancer stem cells. CD44 down
regulation makes breast cancer stem cells sensitize to anti-tumor
drug (doxorubicin). So that combinatorial therapy of CD44
down-regulation and doxorubicin strongly suppressed the tumor
growth in NOD/SCID mice. In another way, we used dendritic cell
therapy to target breast cancer stem cells. Dendritic cells were
loaded with breast cancer stem cells derived antigens. The results
also showed that dendritic cell vaccination inhibits the cancer
development in mice models.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
February 2012 |
First published: |
February 2012 |
Authors: |
Phuc Van Pham
|
Dimensions: |
229 x 152 x 10mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
180 |
ISBN-13: |
978-3-8473-4966-2 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-8473-4966-X |
Barcode: |
9783847349662 |
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