Capillary Electrophoresis of Carbohydrates (Paperback, Softcover reprint of hardcover 1st ed. 2003)

Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic acids and proteins are copied from a template in a repeated series of identical steps using the same enzymes, complex carbohydrates are formed by the sequential actions of cellular glycosyltransferases that specifically recognize unique s- strates. The molecular biology of these transferases and other carbohydra- modifying enzymes is providing important insights on oligosaccharide recognition events. While it is acknowledged that the definition of the protein complement of cells and tissues (the so-called proteome) remains an enormous task in this postgenomic era, the characterization of all glycans produced by individual organisms (referred to as the glycome) presents an equally imp- tant challenge. This task is further complicated by the fact that oligosacc- rides cannot presently be cloned. These complex carbohydrates exist in a staggering diversity of structures, linkages, and branching, thus providing an exquisite molecular repertoire for cellular interactions.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 213
Release date:	November 2010
First published:	2003
Editors:	Pierre Thibault • Susumu Honda
Dimensions:	229 x 152 x 18mm (L x W x T)
Format:	Paperback
Pages:	318
Edition:	Softcover reprint of hardcover 1st ed. 2003
ISBN-13:	978-1-61737-206-3
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Carbohydrates
LSN:	1-61737-206-4
Barcode:	9781617372063

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