The embryonic development of the Central Nervous System (CNS)
requires an orchestrated series of events tightly regulating the
patterning and regionalization of the neural tube, as well as the
proliferation and differentiation of distinct neuronal populations.
All these events are controlled by cascades of activation of
transcription factors that regulate the expression of specific
subsets of genes in restricted regions and neuronal populations of
the developing CNS. Among these transcription factors,
homeobox-containing proteins play a crucial role, and altered
expression of these factors can impact embryonic and adult CNS
functions. In particular, homeobox-containing genes have been
described to crucially regulate differentiation of dopaminergic and
serotonergic neurons during brain development. Classical
pharmacological studies clearly showed that both dopamine and
serotonin markedly regulate seizure susceptibility through specific
receptor pathways. Our recent studies, performed on classical and
conditional knockout mouse lines, demonstrate that altered
embryonic development of dopaminergic and serotonergic neurons
results in altered seizure susceptibility in the adult life.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
United States |
Release date: |
February 2013 |
First published: |
February 2013 |
Authors: |
Prem Prakash Tripathi
|
Dimensions: |
229 x 152 x 6mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
104 |
ISBN-13: |
978-3-659-35492-2 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
|
LSN: |
3-659-35492-9 |
Barcode: |
9783659354922 |
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