Breast cancer is the second leading cause of cancer deaths and is
the most common cancer among women. Although a number of biomarkers
are being used in clinical practice, significant number cases for
breast cancers are detected late and difficult to treat. Therefore,
new biomarkers are in need to improve diagnosis and the
therapeutics for breast cancer. The emergence of proteomics
technologies has facilitated researcher comprehensive differential
expression analyses of proteins in healthy and cancer individuals.
The most commonly used proteomic techniques in breast cancer
research are 2D-PAGE, SELDI-ToF MS, Protein Arrays, ICAT, iTRAQ and
SILAC. Recent advancement in proteomics has also enabled to study
the intracellular signalling pathways that may underlie the
development of breast cancer. Thus, proteomics could play
significant roles in identification of novel biomarkers and/or drug
targets to improve existing prognosis and diagnosis of breast
cancer. This book covers a selection of advances in the realm of
proteomics and its promise for the discovery of biomarkers and drug
targets, and sample preparation of cell culture and clinical
martial for breast cancer research.
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