Diabetes is a worldwide pathology, characterized by a group of
syndromes associated with very high levels of blood sugar.
Pancreatic -cell maintains the blood glucose homeostasis by
secreting insulin. The rise in cytosolic Ca2+ concentration due to
extracellular Ca2+ influx through voltage-gated Ca2+ channels is
the major trigger which stimulates insulin release and acts as a
key regulator for insulin secretion. Ascorbic acid, the most common
antioxidant shares structural similarity with glucose and have
evidences that supplementation of ascorbic acid relieved various
complications of diabetes. MIN6 (Mouse Insulinoma cell line) has
been widely used as a -cell specific cell line which shows glucose
stimulated insulin secretion qualitatively and quantitatively
similar to normal -cells. This study specifically focused on the
role of extracellular calcium and ascorbic acid individually as
well as in association with each other in repairing, reactivation
and rejuvenation of diabetic MIN6 cells first time. This effort
sets up a ground work which can be further explored at molecular
level and clinical trials, which will be helpful in therapeutics
for type II diabetes in future."
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