The use of cultured cells in the clinical diagnosis of hereditary
metabolic dis ease is a rapidly developing subject to which many
different disciplines have brought their expertise and knowledge. A
number of scientists who have in dividually contributed to the
growth of the subject gave invited papers at the Fourteenth
Symposium of the Society for the Study of Inborn Errors of
Metabolism in the University of Edinburgh on 13-16th July, 1976.
These papers form the basis of this monograph which brings together
contributions from the basic sciences and from physicians concerned
primarily with human disease. The cross-fertilization produced by
this interdisciplinary communica tion was invaluable to those
trying to understand and overcome diagnostic problems posed by
hereditary metabolic disease. Cell culture methods and cell
preservation techniques were described by D. G. Harnden and D. E.
Pegg; Dr T. Elsdale outlined some of the factors which control in
vitro cell growth and division. Cell culture methods and cryopreser
vation techniques have allowed the wide distribution of
biochemically abnor mal cells and their study over long periods of
time. It is also evident that when a defect which produces severe
metabolic disorder in man can be studied in the laboratory using
isolated cell cultures a wide variety of investigative procedures
can be focused on to the cellular defect without distress or
discomfort to the patient or relatives."
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