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The Role of Aging in Atherosclerosis - The Sequestration Hypothesis (Hardcover, 2003 ed.)
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The Role of Aging in Atherosclerosis - The Sequestration Hypothesis (Hardcover, 2003 ed.)
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The cover of this book summarizes the central features of the
sequestration hypothesis: Commonplace appearances seen in human
coronary artery, fat stained in paraffin seetions by a new
technique explained in Chapter Eleven, are arranged to suggest
pathways of evolution toward atheroma. The hypothesis formulated
and defended in the pages ofthis book is this: Fibroplasia
progresses upward in column "a" from "la" to "3a" as a
characteristic feature of aging. This starts sooner and progresses
faster in men than in wornen. Numbers ofSMC's remain essentially
constant so that fibroplasia per SMC steadily increases. The rise
upward conveys an increasing propensity to sequester atherogenic
lipids, causing transition rightward into column "b." Sequestered
extracellular lipid then attracts fatty streak elements, especially
foam cells and lyrnphocytes, to propel the arterial site rightward
into column "c." Frame "lc" corresponds to the AHA Lesions
Committee classification type IIb, the progression resistant fatty
streak arising directly without prior lipid sequestration; this can
progress to atheroma, but slowly after much delay, although extreme
provocation can accelerate the process. Such progression is
rightward toward atherorna with thin cap, not upward toward
fibroplastic thickening. Frame "2c" corresponds to the AHA
classification, type Ha, progression prone fatty streaks. These
readily evolve into atheroma, again by horizontal progression.
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Release date: |
May 2003 |
First published: |
May 2003 |
Authors: |
R. E. Tracy
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Dimensions: |
235 x 155 x 17mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
273 |
Edition: |
2003 ed. |
ISBN-13: |
978-1-4020-1223-5 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Cardiovascular medicine
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LSN: |
1-4020-1223-3 |
Barcode: |
9781402012235 |
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