Clinical lung transplantation has seen an early start within the
history of solid organ trans plantation, marked by the 1963 first
lung transplant by James D. Hardy. This was prompted by the
seemingly easy way of joining the transplanted organ to the
recipient by me ans of a few well-defined anastomoses, i.e.
bronchus, pulmonary artery and pulmonary vein carry ing left atrial
cuff. The following decade thus witnessed a number of such mostly
unilateral lung transplants in several centres, in Germany
represented by the two only lung transplants performed by E. S.
Bucherl, then at the Neukolln City Hospital in Berlin in 1969. As
with most other such attempts these two patients suffered early and
lethai graft failure. There was only one single lung transplant
patient who lived up to ten months after the transplant at Gent,
Belgium, having been operated on by Derom in 1969. The alm ost
universal failure during this initial phase was attributed to
bronchial anasto motic insufficiency, pulmonary infection of either
the transplanted lung or the left-in-place contralateral lung and a
far-reaching lack of knowledge how to cope with transplant rejec
tion. In the early 1970s it had become gene rally accepted that
lung transplantation could not be performed successfully."
General
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