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Receptor Regulation (Paperback, Softcover reprint of the original 1st ed. 1981)
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Receptor Regulation (Paperback, Softcover reprint of the original 1st ed. 1981)
Series: World Crop Series
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ROBERT J. LEFKOWITZ, M. D. Receptor Regulation (Receptors and
Recognition, Series B, Volume 13) Edited by R. J. Lefkowitz
Published in 1981 by Chapman and Hall, 11 New Fetter Lane, London
EC4P 4EE (c) 1981 Chapman and Hall The study of hormone and drug
receptors has become one of the most excit ing and rapidly moving
areas of biomedical research. Elucidation of receptor mechanisms
and receptor structure has become the common goal of many
scientists from diverse backgrounds. The rapid advances achieved
have been due, in large part, to the concentrated effort of workers
from a variety of disciplines including classical pharmacology,
biochemistry, endocrinology, cell biology, genetics' and molecular
biology, among others. Hormone and drug receptors appear to be of
three major types, which may be classified by their cellular
locations. Found in the plasma membranes of cells are the receptors
for a wide variety of polypeptide hormones, catecholamines and a
variety of neurotransmitters. Included within this group are those
receptors coupled to the enzyme adenylate cyclase. The second group
of receptors are the soluble cytoplasmic receptors for the steroid
hormones. A third type of hormone receptor is the receptor for the
thyroid hormones which appears to be confined to the nucleus. Not
only may these different types of receptor be distinguished in
terms of their cellular locations but also by their mechanisms of
action."
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