Adaptive immune responses serve as a key defense mechanism for
the control of infections in vertebrates. Immune responses must be
of sufficient strength to contain invading pathogens, antigen
specific responses require regulatory mechanisms to ensure
termination or downmodulation to avoid excessive damage to the host
tissue. For both branches of the adaptive immune system, regulatory
molecules i.e. coreceptors and ligands have been identified that
control the signaling cascades initiated by engagement of the T
cell and B cell antigen receptors. This book describes biological
functions as well as molecular mechanisms of these molecules.
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