Dissolution is important parameter to achieve desired concentration
of drug in systemic circulation for elicit pharmacological
response. The formulation of poorly soluble drugs has been the
subjects of much research, as approximately 40% of new chemical
entities develop in pharmaceutical industries are insoluble in
nature. In the present investigation drugs which are practically
insoluble in gastric fluid and having high permeability through
stomach were selected. The rational for selecting such type was
"Drugs which are only permeable through stomach but due to its
solubility limitation in gastric fluid they can not enter in to
systemic circulation, further more gastric empting time is ranging
form 30 mins to 2 hrs after this time drugs enter in to small
intestine where they can soluble but can not permeable through its
membrane due to its permeation limitation." To improve dissolution
of such drugs in stomach are challenging and rational. Attempts
were made to prepare formulations which would dissolved completely
within 30 minutes or retain in stomach for more than 2 hrs if drugs
can not soluble in 2 hrs even after addition of solubilising
enhancing excipients.
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