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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Advances in Hypertension Research (Hardcover)
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Advances in Hypertension Research (Hardcover)
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Hypertension, also referred to as high blood pressure, is a disease
afflicting almost 1 billion people world-wide. Some 70 million
adults in the United States are affected by hypertension. The
condition also affects about two million teens and children. It is
called the "silent killer" due to the deleterious damaging effects,
such as stroke, myocardial infarction, renal dysfunction, visual
problems, among others, derived from hypertension. It is noteworthy
that one-third of patients in this condition are not even aware
they are hypertensive, as this disease is usually asymptomatic for
many years, even decades, until it finally damages certain critical
organs and the only reliable way to detect its occurrence is to
regularly check blood pressure. Therefore, considerable effort has
been devoted to ascertain the causes of hypertension, as well as
the mechanisms damaging the organ function. Nevertheless, about 95%
of cases have unknown causes and represent the primary or essential
hypertension. This book presents an update of research advances
contributing to a better understanding of relevant clinical models
of hypertension, particularly; the involvement of the role of
oxidative stress in various forms of hypertension as a still
emerging subject. This paradigm could be applied to account for
blood pressure elevation in the metabolic syndrome, renovascular
disease, preeclampsia and chronic kidney disease, among others.
These examples are discussed in the light of recent clinical and
experimental studies providing a rational base for diagnosis and
treatment of the diseases. Each chapter includes a synthesis of the
mechanistic approach supported by the accumulated evidence to
facilitate its comprehension.
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