Heart rejection is a major problem for heart transplant patients.
The best strategy for understanding and preventing organ rejection
is to study experimental animal models. The popular mouse model of
heterotopic cardiac transplantation has been used for over three
decades to help investigators understand the pathogenesis of graft
rejection and in turn, how novel drugs can attenuate the immune
response to transplanted organs. Also, since the genetic blueprint
of mice is well-known, specific genes can be modified to study its
effect on graft acceptance and tolerance. Despite the large
potential for this model, little is known about the physiology,
haemodynamics, and morphology of the transplanted heart and there
is no method to assess objectively graft survival. This work
describes in detail the use of high-frequency ultrasound for
investigating the small transplanted mouse heart. For the first
time, insights are made into blood flow, the effects of graft
rejection, and organ survival with never before seen
high-resolution images unachievable with conventional ultrasound.
This work will be of significant interest to investigators,
clinicians and students in the field.
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