In contrast to most other vertebrates, teleost fish exhibit an
unparalleled capacity to generate stem cells in both the intact and
the injured adult brain.My research is focused on the occurrence,
the extent and the fate of aneuploid cells (genome-modified
individual cells characterized by the loss or gain of whole
chromosomes) generated in the teleostean brain. Aneuploidy arises
through various chromosome segregation defects during the mitotic
divisions of newly-generated cells in the adult brain. Aneuploidy
is observed in 80% of the newly-generated stem cells of the adult
brain, but occurs at a very low rate in liver tissue, as shown by
metaphase chromosome spreads and flow-cytometric DNA content
analysis. The mitotic machinery of adult brain cells was examined
for chromosome segregation defects which showed lagging chromosomes
at metaphase and anaphase, as well as micronuclei and anaphase
bridges, in the intact adult brain. In conclusion, my research
demonstrates the evidence of the generation and maintenance of
aneuploid cells in the adult fish brain that arise through
chromosome missegregation which is a widespread phenomenon in the
teleostean central nervous syst
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