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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Virology
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Retroviruses - Molecular Biology, Genomics and Pathogenesis (Hardcover)
Loot Price: R5,941
Discovery Miles 59 410
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Retroviruses - Molecular Biology, Genomics and Pathogenesis (Hardcover)
Expected to ship within 10 - 15 working days
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Retroviruses comprise a diverse family of enveloped RNA viruses,
remarkable for their use of reverse transcription of viral RNA into
linear double stranded DNA during replication and the subsequent
integration of this DNA into the genome of the host cell. Members
of this family include important pathogens such as HIV-1, feline
leukemia, and several cancer-causing viruses. However, interest in
these viruses extends beyond their disease-causing capabilities.
For example, research in this area led to the discovery of
oncogenes, a major advance in the field of cancer genetics. Studies
of retroviruses have contributed greatly to our understanding of
mechanisms that regulate eukaryotic gene expression. In addition,
retroviruses are proving to be valuable research tools in molecular
biology and have been used successfully in gene therapy (e.g. to
treat X-linked severe combined immunodeficiency). Written by the
top retroviral specialists, this book reviews the genomics,
molecular biology, and pathogenesis of these important viruses,
comprehensively covering all the recent advances. Topics include:
host and retroelement interactions * endogenous retroviruses *
retroviral proteins and genomes * viral entry and uncoating *
reverse transcription and integration * transcription * splicing
and RNA transport * pathogenesis of oncoviral infections *
pathogenesis of immunodeficiency virus infections * retroviral
restriction factors, molecular vaccines, and correlates of
protection * gammaretroviral and lentiviral vectors * non-primate
mammalian and fish retroviruses * simian exogenous retroviruses *
and HTLV and HIV. It is essential reading for every retrovirologist
and it is a recommended text for all virology and molecular biology
laboratories.
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