This volume, written by experts in the field, discusses the current
understanding of the biophysical principles that govern RNA
folding, with featured RNAs including the ribosomal RNAs, viral
RNAs, and self-splicing introns. In addition to the fundamental
features of RNA folding, the central experimental and computational
approaches in the field are presented with an emphasis on their
individual strengths and limitations, and how they can be combined
to be more powerful than any method alone; these approaches include
NMR, single molecule fluorescence, site-directed spin labeling,
structure mapping, comparative sequence analysis, graph theory,
course - grained 3D modeling, and more. This volume will be of
interest to professional researchers and advanced students entering
the field of RNA folding.
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