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Books > Medicine > Other branches of medicine > Pharmacology
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Cytotoxic Drug Resistance Mechanisms (Hardcover, 1999 ed.)
Loot Price: R3,164
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Cytotoxic Drug Resistance Mechanisms (Hardcover, 1999 ed.)
Series: Methods in Molecular Medicine, 28
Expected to ship within 10 - 15 working days
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There is now a range of cytotoxic drugs that have considerable
clinical usefulness in producing responses in tumors and even, in a
small proportion of cases, cure. However, the acquisition of drug
resistance is a major clinical problem and is perhaps the main
limiting factor in successful treatment of cancer. Thus, a tumor
initially sensitive to chemotherapy will, in the majority of cases,
eventually recur as a resistant tumor, which will then progress.
Much of our understanding of drug resistance mechanisms comes from
the study of tumor cell lines grown in tissue culture. We now
understand many of the - lecular mechanisms that can lead to a cell
acquiring resistance to antic- cer drugs; however, we still do not
know which mechanism(s) are those most relevant to the problem of
clinical drug resistance. Indeed, given that many of the cytotoxic
anticancer drugs were discovered by random screening, it is - clear
what features give a clinically useful anticancer drug a sufficient
the- peutic index to be of value. The aim of Cytotoxic Drug
Resistance Mechanisms is to provide pro- cols that are appropriate
for examining the mechanisms of cellular resistance to anticancer
cytotoxics in human tumor samples. Tumor cell lines have been
enormously useful as experimental models of drug resistance
mechanisms, however they have limitations and we need to address
the relevance of such mechanisms in patients' tumors. Examining
drug resistance in tumors is much more problematic than in cell
lines.
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