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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Basis and Treatment of Cardiac Arrhythmias (Hardcover, 2006 ed.)
Loot Price: R11,427
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Basis and Treatment of Cardiac Arrhythmias (Hardcover, 2006 ed.)
Series: Handbook of Experimental Pharmacology, 171
Expected to ship within 10 - 15 working days
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In the past decade, major progress has been made in understanding
mec- nisms of arrhythmias. This progress stems from much-improved
experim- tal, genetic, and computational techniques that have
helped to clarify the roles of speci?c proteins in the cardiac
cycle, including ion channels, pumps, - changer, adaptor proteins,
cell-surface receptors, and contractile proteins. The interactions
of these components, and their individual potential as therap- tic
targets, have also been studied in detail, via an array of new
imaging and sophisticated experimental modalities. The past 10
years have also led to the realization that genetics plays a
predominant role in the development of lethal arrhythmias. Many of
the topics discussed in this text re?ect very recently undertaken
research directions including the genetics of arrhythmias, cell
signaling mo- cules as potential therapeutic targets, and
traf?cking to the membrane. These new approaches and
implementations of anti-arrhythmic therapy derive from many decades
of research as outlined in the ?rst chapter by the distinguished
professors Michael Rosen (Columbia University) and Michiel Janse
(University of Amsterdam). The text covers changes in approaches to
arrhythmia therapy over time, in multiple cardiac regions, and over
many scales, from gene to protein to cell to tissue to organ.
General
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