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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Hepatitis B and D Protocols - Volume 2: Immunology, Model Systems, and Clinical Studies (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Loot Price: R3,392
Discovery Miles 33 920
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Hepatitis B and D Protocols - Volume 2: Immunology, Model Systems, and Clinical Studies (Paperback, Softcover reprint of hardcover 1st ed. 2004)
Series: Methods in Molecular Medicine, 96
Expected to ship within 10 - 15 working days
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Despite the availability of an effective vaccine, there are still
400 million people, worldwide who are chronically infected with
hepatitis B virus (HBV). For them, the vaccine, as currently
applied, has no value. Given the possible consequences of HBV
infection, the number of those chronically infected with HBV
presents an enormous public health challenge. For example, the
major etiology of hepatocellular carcinoma (HCC) is chronic
infection with HBV. Although fifth in cancer incidence, worldwide,
HCC/liver cancer is the third leading cause of cancer death. The
high mortality as- ciated with HCC arises because the disease is
often detected late and is unresponsive to treatment. The number of
deaths caused by PHCC is expected to rise over the next 20 years.
Those chronically infected with HBV have a life risk of death to
HCC of between 10 and 25%. Even the limited efficacy of drugs for
the treatment of chronic HBV helps underscore the point that this
disease is responsive to therapy. Drugs that target the polymerase
(e. g. , hepsera and lamivudine) and interferon alpha represent two
distinct strategies and show that both conventional antiviral and
immunothe- peutic approaches can be used in management. However,
the current inventory of therapeutics is inadequate. Interferon
alpha is of limited value, only parenterally ava- able, and fraught
with adverse reactions.
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