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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Adenosine, Cardioprotection and Its Clinical Application (Paperback, Softcover reprint of the original 1st ed. 1997)
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Discovery Miles 44 300
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Adenosine, Cardioprotection and Its Clinical Application (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Developments in Cardiovascular Medicine, 194
Expected to ship within 10 - 15 working days
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The immense growth in the number of articles on adenosine
cardioprotection in recent years has been related in large part to
the hypothesis that adenosine plays a role in ischemic
preconditioning. Ischemic preconditioning is the phenomenon in
which a brief period of ischemia (and reperfusion) prior to a more
prolonged occlusion reduces myocardial infarct size. This form of
myocardial protection has received much interest because ischemic
preconditioning has been shown to be the most potent means of
reducing infarct size in all animal models so far tested. Within
the last six years, the principal focus of adenosine
cardioprotection research has centered on the role of adenosine
receptors. It is currently thought that adenosine protects the
ischemic heart primarily via the activation of adenosine A1
receptors located on the cardiac myocytes. Adenosine is used
clinically for terminating supraventricular tachycardia, and as a
diagnostic tool in coronary imaging, and has been used
postoperatively for blood pressure control after heart
surgery.There are also recent reports that adenosine may be safely
tolerated and a potentially beneficial additive to cardioplegic
solutions during open heart surgery in humans. There is even
evidence that ischemic preconditioning may occur in humans under
various clinical situations. This volume contains chapters from
contributors to the first three symposia on 'Adenosine,
Cardioprotection, and its Clinical Application'. All aspects of
adenosine cardioprotection and ischemic preconditioning, including
potential mechanisms and clinical applications, are discussed by
experts in these areas. The reader will find this book to be an
excellent source of information on these topics, as well as a guide
to future experiments.
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