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New Angiogenesis Research (Hardcover, Illustrated Ed)
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New Angiogenesis Research (Hardcover, Illustrated Ed)
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Angiogenesis -- the growth of new blood vessels -- is an important
natural process occurring in the body, both for health and as
related to disease. Angiogenesis occurs in the healthy body to help
heal wounds and to help restore blood flow to tissues after injury
or insult. In females, Angiogenesis also occurs during the monthly
reproductive cycle (to rebuild the uterus lining, to mature the egg
during ovulation) and during pregnancy (to build the placenta, the
circulation between mother and foetus). The healthy body controls
Angiogenesis through a series of 'on' and 'off' switches. The main
'on' switches are known as Angiogenesis-stimulating growth factors.
The main 'off' switches are known as Angiogenesis inhibitors. When
angiogenic growth factors are produced in excess of angiogenesis
inhibitors the balance is tipped in favour of blood vessel growth.
When inhibitors are present in excess of stimulators, angiogenesis
is stopped. The normal, healthy body maintains a perfect balance of
angiogenesis modulators. In general, angiogenesis is 'turned off'
by the production of more inhibitors than stimulators. Tumour
angiogenesis is the proliferation of a network of blood vessels
that penetrates into cancerous growths, supplying nutrients and
oxygen and removing waste products. Tumour angiogenesis actually
starts with cancerous tumour cells releasing molecules that send
signals to surrounding normal host tissue. This signalling
activates certain genes in the host tissue that, in turn, cause
proteins to encourage growth of new blood vessels. This new book
examines its angiogenesis within the context of theory and its
applications to cancer treatment.
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