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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Controlled Clinical Trials in Neurological Disease (Hardcover, 1990 ed.)
Loot Price: R8,204
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Controlled Clinical Trials in Neurological Disease (Hardcover, 1990 ed.)
Series: Foundations of Neurology, 1
Expected to ship within 12 - 17 working days
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The evaluation of the efficacy and safety of a clinical tool, be it
a diagnostic technique, a preventive methodology, or a therapeutic
intervention, is an im portant responsibility of physicians. The
history of medicine is characterized by the authoritarianisms of
teachers and of organizations giving way to the clinical experience
of physicians; authoritarian dictum was replaced by case report and
then by case series. As physicians learned to substitute the
analysis of data for the inconsistencies of dictums and anecdotes,
the problems of the case series as an investigative tool became
more evident: patient selection criteria, measurements of outcome,
significance of results, and extrapolation of conclusions to the
community of patients. In response to these issues, the methodology
of the controlled clinical trial has evolved and with it the instru
ments of study design and of biostatistics as aids to study design
and data analysis. The medical - surgical armamentarium has evolved
from being dependent solely upon the observations and conclusions
of a skilled clinician to being constructed upon the systematic
collection and evaluation of data by a team of skilled clinicians
and their statistical colleagues: this is the controlled clinical
trial. During the past two decades, the evaluation of clinical
approaches to pre vention and therapy has become particularly
important to clinicians concerned with nervous system dysfunction.
There has been and continues to be an explosion of information from
the basic neurosciences and from the applica tion of biotechnology
to the nervous system."
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