Antibacterial agents act against bacterial infection either by
killing the bacterium or by arresting its growth. They do this by
targeting bacterial DNA and its associated processes, attacking
bacterial metabolic processes including protein synthesis, or
interfering with bacterial cell wall synthesis and
function."Antibacterial Agents" is an essential guide to this
important class of chemotherapeutic drugs. Compounds are organised
according to their target, which helps the reader understand the
mechanism of action of these drugs and how resistance can arise.
The book uses an integrated "lab-to-clinic" approach which covers
drug discovery, source or synthesis, mode of action, mechanisms of
resistance, clinical aspects (including links to current
guidelines, significant drug interactions, cautions and
contraindications), prodrugs and future improvements.Agents covered
include: agents targeting DNA - quinolone, rifamycin, and
nitroimidazole antibacterial agentsagents targeting metabolic
processes - sulfonamide antibacterial agents and trimethoprimagents
targeting protein synthesis - aminoglycoside, macrolide and
tetracycline antibiotics, chloramphenicol, and oxazolidinonesagents
targeting cell wall synthesis - β-Lactam and glycopeptide
antibiotics, cycloserine, isonaizid, and daptomycin
"Antibacterial Agents" will find a place on the bookshelves of
students of pharmacy, pharmacology, pharmaceutical sciences, drug
design/discovery, and medicinal chemistry, and as a bench reference
for pharmacists and pharmaceutical researchers in academia and
industry.
General
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