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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Targeted Drug Delivery (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R3,047
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Targeted Drug Delivery (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: Handbook of Experimental Pharmacology, 100
Expected to ship within 10 - 15 working days
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The chapters in this volume describe a powerful emerging approach
for the therapy of disease. Targeted drug delivery, that is control
of the kinetic behavior, tissue distribution, and subcellular
localization of pharmaco logically active agents, offers an
important means for improving the efficacy of a wide variety of
drug therapies. This is particularly true for therapeutic
approaches based on newer agents which are the products of
recombinant DNA research. These agents, be they peptides, proteins,
or oligonucleotides, tend to be larger, more complex, and less
stable than traditional drugs. Thus they stand to benefit most from
drug delivery systems which can protect them from premature
degradation and which can carry them to critical target sites in
the body. This volume examines several important aspects of the
current state of drug delivery research; it also attempts to
project future directions for this field. Successful approaches to
drug targeting are based, first of all, on a sophisticated
understanding of the biological barriers encountered by the
drug-carrier complex as it moves from the portal of administration
to the ultimate target site. A second aspect of successful drug
delivery is appro priate matching of the disease entity with the
pharmacologically active substance and with the delivery system.
Thus it is important to be aware of the variety of delivery
technologies which currently exist and to be sensitive to their
strengths and limitations.
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