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Principles of Pharmacogenetics and Pharmacogenomics (Hardcover)
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Principles of Pharmacogenetics and Pharmacogenomics (Hardcover)
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The study of pharmacogenetics and pharmacogenomics focuses on how
our genes and complex gene systems influence our response to drugs.
Recent progress in the science of clinical therapeutics has led to
the discovery of new biomarkers that make it technically easier to
identify groups of patients which are more or less likely to
respond to individual therapies. The aim is to improve personalised
medicine - not simply to prescribe the right medicine, but to
deliver the right drug at the right dose at the right time. This
textbook brings together contributions from leading experts to
discuss the latest information on how human genetics impacts drug
response phenotypes. It presents not only the basic principles of
pharmacogenetics, but also clinically valuable examples that cover
a broad range of specialties and therapeutic areas. The first
section of the book outlines critical concepts in pharmacogenetics
and pharmacogenomics, including genetic testing, genotyping
technologies, and adverse drug effects. The next section discusses
the legal, ethical, and social implications of pharmacogenomics.
The second half of the book details many of the main therapeutic
areas, including oncologic drugs, cardiovascular drugs, statins,
drug-induced long QT syndrome, diabetes drugs, respiratory drugs,
gastrointestinal drugs, rheumatoid arthritis drugs, obstetric
drugs, psychiatric drugs, pain and anesthesia drugs, HIV and
antiretroviral drugs, pediatrics, and fetal and neonatal medicine.
This textbook is an invaluable introduction to pharmacogenetics and
pharmacogenomics for health care professionals, medical students,
pharmacy students, graduate students and researchers in the
biosciences. RESOURCES @ www.cambridge.org/altman Link to the
Pharmacogenomics Knowledgebase study guides images from the book
discussion questions content updates.
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