In recent years there has been an increasing need for
transplantation, but the number of donor livers available has
increased only slightly, despite intensive public relations
activities. New concepts in the field of transplantation, for
instance the transplantation of living donor organs or the
splitting of organs, are urgently required, to safeguard the
treatment of patients with severe liver disease. The development
and clinical application of cell therapy for patients with liver
disease could soon present a significant enhancement of the
therapeutic options. The aim of such cell therapy is to repair or
improve the biological function of the chronically and acutely
damaged liver. Even though systematic trials are not available,
individual case reports and small series already show promising
clinical results.
Present concepts of cell therapy for liver diseases based on the
use of primary hepatocytes have recently been considerably extended
through new data on the biology of stem cells. The adult
haematopoetic stem cell as a pool for hepatocyte grafts - what
would be the perspectives for the clinical application?
This book is the proceedings of the Falk Symposium No. 126 on
Hepatocyte Transplantation' (Progress in Gastroenterology and
Hepatology Part III) held in Hannover, Germany, October 2-3, 2001,
and is a forum for basic research, but also for questions
concerning clinical applications in the field of hepatocyte
transplantation.
General
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