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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Mechanisms of Lymphocyte Activation and Immune Regulation II (Paperback, Softcover reprint of the original 1st ed. 1989)
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Mechanisms of Lymphocyte Activation and Immune Regulation II (Paperback, Softcover reprint of the original 1st ed. 1989)
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The ac ti vati on of Iymphocytes by physiologie ligands has become
a central area of study for immunologists. Furthermore, Iymphocytes
offer many advantages for the study of general aspects of
receptor-mediated cellular activation. For these reasons, research
on the cellular and molecular aspects of the activation of
Iymphocytes by antigens, antigen analogues, Iymphokines and other
growth factors has expanded enormously in the last several years.
Aseries of conferences, "The International Conferences on
Lymphocyte Activation," has been initiated to meet the growing need
for a forum for the discussion of the topics that are included
within the area of Iymphocyte activation. This volume represents
the proceedings of the Second International Conference on
Lymphocyte Activation and Immune Regulation, held on February
18-20, 1988 at Newport Beach, California. The proceedings comprise
four major sections. The first deals with the T cell receptors and
T cell activation. It includes a model for the T cell receptor
interaction with a complex of MHC plus antigen, structure of y c'i
T cell receptor and their distinct isotypic forms, the role of zeta
chain in the expression and structure of T cell receptors and its
role in transmembrane signalling. The use of somatic cell mutants
in the study of signal transduction function of the T cell antigen
receptors and the early and late steps of signal transduction via a
/ ss T cell antigen receptors are discussed."
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