The eye can become involved in immune-mediated diseases that affect
it alone or as part of a multi-organ disease process. Much
immunological attention has been focused on other organs affected
by these processes and the subject of the immunology of eye
diseases is a relatively new one. Many of these diseases that
involve the eye are not life-threatening but can result in devastat
ing loss of sight that if bilateral, will have major effects on the
patient's life. Systemic immunological investigations are generally
unhelpful in these patients and one of the major problems in this
field has been the lack of diseased tissue available for
examination to determine the pathological processes involved. Our
poor understanding of basic mechanisms of disease in the eye has
meant that treatment of many of these conditions is often
inadequate. It has become possible to apply in the eye many ofthe
techniques used to investigate the role of the immune system in
other systems. Animal models of many of the disease processes have
also allowed dissection of the immune response both within and
outside the eye. It is my belief that a greater understanding of
the mechanisms by which the structures in the eye become damaged
will allow more specific and effective therapeutic strategies to be
devised."
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