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Tubulointerstitial and Cystic Disease of the Kidney (Paperback, Softcover reprint of the original 1st ed. 1995)
Loot Price: R1,602
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Tubulointerstitial and Cystic Disease of the Kidney (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Current Topics in Pathology, 88
Expected to ship within 10 - 15 working days
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Over recent years, much renal research has focused on the pathology
of the glomerulus, where many primary renal insults occur. However,
nearly thirty years have passed since Risdon's study made the
apparently anomalous observation that the extent of damage to the
tubulointerstitial compartment is the major determinant of renal
outcome in a variety of human glomerular diseases. This volume
covers various aspects of tubulointerstitial disease, and starts
with an update on cystic disease of the kidney, by Drs. WILSON and
FALKENSTEIN, which includes recent experimental data on the altered
properties of cystic epithelium. My own chapter gives an overview
of the mechanisms of tubulo interstitial damage in progressive
renal disease and includes a dis cussion of the possible role of
cytokines, vasoactive peptides and peptide growth factors found
over the last few years to be secreted by renal tubular cells.
These comments are expanded in the contribution by Dr. WOLF and
Professor NEILSON, who provide a detailed account of the cellular
biology of tubulointerstitial growth. The earliest studies from the
19608 attempted to correlate histo morphometry of the
tubulointerstitium with renal outcome. Dr. KHAN and Professor
SINNIAH provide us with an update on mor phometric methods as
applied to the kidney using new techniques. Similar techniques are
employed by Dr. IVANYI and Professor OLSEN who give a detailed
stereomorphological account of tubulitis both in acute allograft
rejection, where its- recognition is central to the diagnosis, and
in other forms of tubulointerstitial disease."
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