Polycystic ovary syndrome (PCOS) is a heterogenous endocrinal
disorder that affects women in their reproductive age. PCOS is an
important risk factor for CVD, DM and endometrial cancer.
Sympathetic nervous system is very important in the etiology of
PCOS and regulation of ovarian physiology. Hyperactivity of the
sympathetic nervous system, stress and opioid endorphin release are
associated with PCOS. Endogenous opioids ( endorphin) are
inhibitory neurotransmitters. PCOS is related to the peripheral and
central factors e.g. opioid peptide endorphin which influences
sympathetic nervous system. In PCOS opioid system is dysregulated
and this cause abnormality in reproductive and metabolic hormones.
High opioid tone is found in PCO women. High opioid activity is
suppressed by the antagonist Naloxone or Naltrexone. Yohimbine is
antagonist of sympathetic nervous system and decreases sympathetic
activity and reduces PCOS. Naloxone, Yohimbine and their combined
therapy was very effective and cause reduction in PCOS."
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