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New Natural Active Constituents Against Schistosoma Mansoni (Paperback)
Loot Price: R1,952
Discovery Miles 19 520
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New Natural Active Constituents Against Schistosoma Mansoni (Paperback)
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Schistosomiasis is one of the leading causes of morbidity and
mortality associated with parasitic infections in endemic areas,
affecting nearly 300 million people in 76 countries all over the
world. Adult worms of Schistosoma mansoni reside in the mesenteric
venous plexus of the bowel, from where the eggs are frequently
swept back to the liver via the portal blood to induce delayed
hypersensitivity response. The major pathology is granulomatous
inflammation, which is a cellular response to antigens secreted by
the internal membrane and miracidia of schistosome eggs.
Subsequently, the granulomas heal, resulting in a unique form of
periportal fibrosis followed by portal hypertension as the main
complication. In the few past years, the schistosomiasis control
initiative and endemic country programs treated millions of people
with praziquantel (PZQ), the single antischistosomiasis drug in
widespread use. There was already clinical and laboratory evidence
for the existence of PZQ resistance parasites, and widespread use
is expected to generate strong selective pressure for drug
resistance. Thus, the new trend nowadays is the use of natural
plant extracts as new safe and effective drugs.
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