The Guest Editors have focused on methods of diagnosing and
evaluating IBD to help guide optimal treatment to maximize clinical
outcomes and minimize risks. Authors have provided state-of-the-art
updates with practical information/guidelines/algorithms and
cutting-edge data for incorporation into practice. The first set of
articles deals with endoscopy: its role in diagnosis and monitoring
IBD; the growing importance of chromoendoscopy in IBD surveillance
exams; assessment of post-operative recurrence; and finally the
emerging role of capsule endoscopy. The second section focuses on
specific scenarios that IBD physicians encounter frequently: health
maintenance in IBD focusing on proper vaccinations; the growing
problem of Clostridium difficile in IBD; assessment of pouch
problems; optimal evaluation of perianal disease; the state of the
art in using thiopurines including use of allopurinol to optimize
metabolites and optimizing the use of infliximab by measuring
levels and antibodies to infliximab; factors to consider in
choosing monotherapy versus combination therapy and communication
of risk/benefit to patients; and finally disability assessment in
IBD. The third and final section highlights noninvasive methods to
evaluate IBD: clinical predictors of aggressive or disabling
disease; the evolving role of specific antibodies in diagnosing,
subtyping and most recently prognosticating in IBD; stool markers
(calproctectin and lactoferrin) for evaluating and monitoring IBD;
the growing role of imaging modalities with emphasis on MR
enterography and CT enterography; and finally, the genetics of IBD
and the potential role of genetic testing in the
diagnosis/prognosis and tailoring of therapy.
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