Secondary hyperparathyroidism (SHPT) develops frequently in
patients with "End Stage Renal Disease" because the production of
1, 25 (OH) 2- vitamin D (calcitriol) decreases in the kidneys.
That's why patients may develop osteodystrophy or osteomalacia. The
functional role of vitamin D3 under normal body condition is to
regulate secretion of parathyroid hormone (PTH) synthesis and
release. Parameters such as calcium, phosphate and vitamin D3 act
upon PTH. In normal subjects, the homeostasis of these parameters
is strongly interconnected but in renal failure, the metabolism of
each of these parameters may be deregulated. The diseased kidney is
unable to produce vital hormone that is called erythropoietin which
increases synthesis of red blood cells. The anemic condition is
seen in CKD (chronic kidney disease) because erythropoietin
production become reduced. In Pakistan, CKD patients are
continuously increasing annually. We conducted a blood and
serosurvey study in Lahore metropolitan city of Punjab, Pakistan to
see the co-relation between SHPT and CKD. This epidemiological
research of public health will be beneficial for onward broad
demographic surveillance programs.
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