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Hepatoprotective effects of medicinal plants on CCL4 liver toxicity (Paperback)
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Discovery Miles 21 280
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Hepatoprotective effects of medicinal plants on CCL4 liver toxicity (Paperback)
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CCl4 is a halogen aliphatic hydrocarbon derived from methane with
an aromatic sweet odor, and heavier than water in which it is
sparingly soluble. Its use is very much restricted on account of
the fact that its toxicity can manifest itself after simple
inhaling. CCl4 has been widely used as a dry-cleaning solvent and
in-fire-extinguishers because it is a non-flammable liquid. The
experimental model of CCl4 treatment in rats has been extensively
used to study liver fibrogensis. The bio-activation of CCl4 is
complex and implicated both reductive and oxidative pathways. CCl4
is widely used to treat animals as a liver injury model because
damage by CCl4 is regarded as the analogue of liver damage caused
by a variety of hepatotoxins in humans. Liver disease is a
worldwide problem; conventional drugs used in the treatment of
liver disease are sometimes inadequate and can have serious adverse
effects. It is; therefore, necessary to search for alternative
drugs for treatment of liver disease to replace currently used
drugs of doubtful efficacy and safety, so there is a worldwide
trend to go back to traditional medicinal plants in use for
treatment of liver ailments.
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